Life Drinker

You really want to focus on the stats here. Hitting minimum thresholds. The first is speed. You can't be too slow. Get your speed above 250 for Amius hard mode. Next you will need accuracy. You need 400-ish with an accuracy banner and 450+ without. If you can't land the Heal Reduction there is no point bringing her to the fight. You will need someone with Brimstone if you want to make the fight quicker/easier as well.

The next and biggest worry possibly in the fight is your health. The big hitting ability from Amius ignores defense so building her with as much health as possible is the second priority. We want her to live through the hits. We don't want Amius going crazy. The more controlled the fight is, the better. Making her tanky enough to survive is quite a feat.

If you can manage to get great accuracy, great max health and some defense, then start racking up the resistance. The ability to resist debuffs in this fight, like the Stun, make it all that much smoother. You can always bring cleansers to the fight as well and build them faster with high resist. That'll work, too.

* Some artifact sets have upgraded versions available. If you have a better upgraded version of this recommended artifact set, definitely use that instead.

Conventional wisdom says when you have the best single target nuker in the game you build them to nuke but not in this case. Conventional wisdom this time says most of your damage comes from Brimstone/poisons and against this boss you should focus on trying to stay alive. So that is what we are going to do here. Little Miss Annie has low base stats in health and defense. At the end you can decide whether you have enough accuracy or not, then decide between more accuracy or resistance. Being able to resist stuns and debuffs is a great way to keep Heal Reduction up as much as possible.

Starting with the defense tree, we're going to get ourselves some damage reduction from critical hits as well as some resistance. Amius A1 in his alternative form can hit really hard and can critical hit. It is also a single target attack. So having more defense and aoe damage mitigation from Tough Skin and Blast Proof is a pure waste. We grab Rejuvenation to get back to Resurgent and Shadow Heal. You will want to stay topped up at full health as much as possible throughout the fight. The boss heals up a ton as well.

Delay Death mitigation is fantastic. Retribution and Deterrence will help keep the Heal Reduction up, especially if you can resist the stun. I have enough accuracy in my build that I went with Unshakeable for my tier 6 mastery (which I would recommend to min/max) instead of Eagle Eye but you do you.

Now down the support tree, if you can find enough accuracy in your gear, it might be better to go with Steadfast and Shieldbearer for the extra 800 health and 5% extra shield you will get if/when you die and are revived. If you need the extra accuracy, then by all means get it. You will need to land the Heal Reduction debuff (and possibly Brimstone), that is why you brought her in the first place. We're grabbing Swarm Smiter either way. Go ahead and snag Lore of Steel for more stat boosts.

You could grab Sniper to round out the list to help land the Heal Reduction but I prefer to have the Heal Reduction up for one more turn with Master Hexer. That should do it, unless you really need Eagle Eye. Then by all means grab it, too. Just remember, no Cycle of Magic.